FDA says Sandy delays decisions on some drugs

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(Reuters) – Health regulators will delay decisions on some drugs for up to two days because of the massive storm Sandy, which closed the federal government.


The Food and Drug Administration said on Friday that the delay in meeting regulatory timelines for prescription drugs, medical devices and biosimilar drugs would apply to those with target dates around October 29 and 30, when offices were closed.





















For those drugs with target dates on October 31 or later, the agency will consider whether a delay is warranted, but it will not exceed two days.


Sandy hit the East Coast late on Monday. The U.S. government closed ahead of the storm, and again on Tuesday due to widespread power outages and transit issues.


The FDA has set times to review drugs under a user fee program that manufacturers help fund in return for the agency’s meeting certain performance goals. For instance, it must review a certain percentage of drug applications within a set time.


New drug application target approval dates under the Prescription Drug User Fee Act, or PDUFA, are closely watched because they indicate when companies will be able to start selling their new products.


The Biosimilar User Fee Act – which applies to a new generation of generic biotech treatments – and the Medical Device User Fee Act also have approval schedules.


The FDA also said that applications submitted while it was closed might have adjusted timelines.


(Reporting by Caroline Humer; Editing by Lisa Von Ahn)


Medications/Drugs News Headlines – Yahoo! News



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Tempers rise as temps fall after Sandy

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Tempers are beginning to flare as Sandy's victims woke in cold, dark homes today to face yet another grinding day of waiting for help while temperatures are forecast to drop into the 30s with a possible Nor'easter on the way.



Nearly 4 million people spent a fourth day without power and were told some will have to wait weeks.



In the meantime, they waited for hours in line yet again for scarce gasoline supplies, water and food, or endured marathon commutes.



Police have been keeping order at hours-long gas station lines, but the fight for fuel is starting to get nasty. Authorities say a motorist was arrested after he tried to cut in line at a gas station in Queens Thursday and allegedly pointed a pistol at another motorist who complained, according to the Associated Press.



The man was identified as Sean Bailey, 35, and he faces charges of menacing and criminal possession of a weapon.



Conditions will worsen for those without power as temperatures dip into the 30s this weekend and the National Weather Service warns that a Nor'easter could rake the Northeast coastline starting Tuesday.



In addition, the death toll from Sandy's rampage edged up to 90.



Some parts of the area hammered by Sandy feel they have been left behind in the rush to restore power to Manhattan.



Staten Island was one of the hardest-hit communities in New York City. More than 80,000 residents are still without power, many are homeless, and at least 19 people died there because of the storm.



Hurricane Sandy: Full Coverage



Four days after the storm, supplies are finally making their way to the borough and Staten Island Borough President James Molinaro is boiling over in anger at what he sees as a slow relief effort.



"This is America, not a third world nation. We need food, we need clothing," Molinaro said.



Staten Island resident Desi Caruso told ABC News said Sandy has destroyed his neighborhood.



"This neighborhood, we are close. We like each other and now all of our lives here are going to separate and we're going to be broken apart," Caruso said.



Photos: Assessing Sandy's Destruction



Caruso, a music producer who has lived in Staten Island for 20 years, plans to move because the risk of another storm causing massive damage is too great.



"Just how you see everything look, that's how my life feels right now. Just a mess. It's a mess," he said.



Red Cross worker Josh Lockwood, on Staten Island, defended relief efforts.



"So many people are in need right now on such a scale that getting the materials to them as quickly as we can so that their needs are met, that's the chief challenge," said Lockwood.



The Red Cross says it's trying to get more out-of-town volunteers to help with storm relief efforts in the Northeast. Volunteer Joe Hawkins, of Greenville, S.C., is helping people in Staten Island.



"I've been on a lot of disasters, you know, from Katrina on, but some of your areas down near the coast are bad as I've ever seen," Hawkins said.



Some on the New Jersey coastline were hit just as hard as Staten Island residents and they were allowed back into their communities Thursday to get their first look at the devastation.



"That's it. I have nothing. I can't get to my job. I had two cars down there because we thought they'd be safe. They're gone," Marianne Russell, of Moonachie, N.J., told WABC.



"A lot of tears are being shed today," said Dennis Cucci, whose home near the ocean in Point Pleasant Beach was heavily damaged. "It's absolutely mind-boggling."



President Obama held a call with state and local officials from New York, including New York Gov. Andrew Cuomo, to discuss the repair effort late Thursday night, according to a White House official.



Homeland Security Secretary Janet Napolitano and FEMA Deputy Administrator Richard Serino will travel to Staten Island today to meet with state and local officials and inspect recovery efforts.



New York City Mayor Michael Bloomberg said the main concern now is over the elderly and poor all but trapped on upper floors of housing complexes in the powerless buildings.



"Our problem is making sure they know that food is available," Bloomberg said Thursday, as officials expressed concern about people having to haul water from fire hydrants up darkened flights of stairs.



In Manhattan's Chelsea neighborhood, Mary Wilson, 75, walked downstairs from her 19th floor apartment for the first time Thursday because she ran out of bottled water and felt she was going to faint. She said she met people on the stairs who helped her down.




"I did a lot of praying: 'Help me to get to the main floor.' Now I've got to pray to get to the top," she said, after buying water from a convenience store
.
"I said, 'I'll go down today or they'll find me dead," she added.



As essentials dwindle in powerless areas, reports of looting have occurred. Early Thursday morning 18 individuals were arrested for burglary of a Key Food in Coney Island, according to police.



In Far Rockaway, Queens, four arrests were made Thursday stemming from the entry of a closed Radio Shack.



ABC News' Alexis Shaw, Jennifer Abbey, ABC News Radio and The Associated Press contributed to this report.

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Apple's Cook fields his A-team before a wary Wall Street

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SAN FRANCISCO (Reuters) - Apple Inc Chief Executive Tim Cook's new go-to management team of mostly familiar faces failed to drum up much excitement on Wall Street, driving its shares to a three-month low on Wednesday.


The world's most valuable technology company, which had faced questions about a visionary-leadership vacuum following the death of Steve Jobs, on Monday stunned investors by announcing the ouster of chief mobile software architect Scott Forstall and retail chief John Browett -- the latter after six months on the job.


Cook gave most of Forstall's responsibilities to Macintosh software chief Craig Federighi, while some parts of the job went to Internet chief Eddy Cue and celebrated designer Jony Ive.


But the loss of the 15-year veteran and Jobs's confidant Forstall, and resurgent talk about internal conflicts, exacerbated uncertainty over whether Cook and his lieutenants have what it takes to devise and market the next ground-breaking, industry-disrupting product.


Apple shares ended the day down 1.4 percent at 595.32. They have shed a tenth of their value this month -- the biggest monthly loss since late 2008, and have headed south since touching an all-time high of $705 in September.


For investors, the management upheaval from a company that usually excels at delivering positive surprises represents the latest reason for unease about the future of a company now more valuable than almost any other company in the world.


Apple undershot analysts targets in its fiscal third quarter, the second straight disappointment. Its latest Maps software was met with widespread frustration and ridicule over glaring mistakes. Sources told Reuters that Forstall and Cook disagreed over the need to publicly apologize for its maps service embarrassment.


And this month, Apple entered the small-tablet market with its iPad mini, lagging Amazon.com Inc and Google Inc despite pioneering the tablet market in 2010.


Investor concerns now center around the demand, availability and profitability of new products, including the iPad mini set to hit stores on Friday.


"The sudden departure of Scott Forstall doesn't help," said Shaw Wu, an analyst with Sterne Agee. "Now there's some uncertainty in the management."


"There appears to be some infighting, post-Steve Jobs, and looks like Cook is putting his foot down and unifying the troops."


Apple declined to comment beyond Monday's announcement.


Against that backdrop, Cook's inner circle has some convincing to do. In the wake of Forstall's exit, iTunes maestro Eddy Cue -- dubbed "Mr Fixit", the sources say -- gets his second promotion in a year, taking on an expanded portfolio of all online services, including Siri and Maps.


The affable executive with a tough negotiating streak who, according to documents revealed in court, lobbied Jobs aggressively and finally convinced the late visionary about the need for a smaller-sized tablet, has become a central figure: a versatile problem-solver for the company.


Ive, the British-born award-winning designer credited with pushing the boundaries of engineering with the iPod and iPhone, now extends his skills into the software realm with the lead on user interface.


Marketing guru Schiller continues in his role, while career engineer Mansfield canceled his retirement to stay on and lead wireless and semiconductor teams. Then there's Federighi, the self-effacing software engineer who a source told Reuters joined Apple over Forstall's initial objections, and has the nickname "Hair Force One" on Game Center.


"With a large base of approximately 60,400 full-time employees, it would be easy to conclude that the departures are not important," said Keith Bachman, analyst with BMO Capital Markets. "However, we do believe the departures are a negative, since we think Mr. Forstall in particular added value to Apple."


TEAM COOK


Few would argue with Forstall's success in leading mobile software iOS and that he deserves a lot of credit for the sale of millions of iPhones and iPads.


But despite the success, his style and direction on the software were not without critics, inside and outside.


Forstall often clashed with other executives, said a person familiar with him, adding he sometimes tended to over-promise and under-deliver on features. Now, Federighi, Ive and Cue have the opportunity to develop the look, feel and engineering of the all-important software that runs iPhones and iPads.


Cue, who rose to prominence by building and fostering iTunes and the app store, has the tough job of fixing and improving Maps, unveiled with much fanfare by Forstall in June, but it was found full of missing information and wrongly marked sites.


The Duke University alum and Blue Devils basketball fan -- he has been seen courtside with players -- is deemed the right person to accomplish this, given his track record on fixing services and products that initially don't do well.


The 23-year veteran turned around the short-lived MobileMe storage service after revamping and wrapping it into the reasonably well-received iCloud offering.


"Eddy is certainly a person who gets thrown a lot of stuff to ‘go make it work' as he's very used to dealing with partners," said a person familiar with Cue. The person said Cue was suited to fixing Maps given the need to work with partners such as TomTom and business listings provider Yelp.


Cue's affable charm and years of dealing with entertainment companies may come in handy as he also tries to improve voice-enabled digital assistant Siri. He has climbed the ladder rapidly in the past five years and was promoted to senior vice president last September, shortly after Cook took over as CEO.


Both Cue and Cook will work more closely with Federighi, who spent a decade in enterprise software before rejoining Apple in 2009, taking over Mac software after the legendary Bertrand Serlet left the company in March last year


Federighi was instrumental in bringing popular mobile features such as notifications and Facebook integration onto the latest Mac operating system Mountain Lion, which was downloaded on 3 million machines in four days.


The former CTO of business software company Ariba, now part of SAP, worked with Jobs at NeXT Computer. Federighi is a visionary in software engineering and can be as good as Jobs in strategic decisions for the product he oversees, a person who has worked with him said.


His presentation skills have been called on of late, most recently at Apple annual developers' gathering in the summer.


Then there's Ive, deemed Apple's inspirational force. Among the iconic products he has worked on are multi-hued iMac computers, the iPod music player, the iPhone and the iPad.


Forstall's departure may free Ive of certain constraints, the sources said. His exit brought to the fore a fundamental design issue -- to do or not to do digital skeuomorphic designs. Skeuomorphic designs stay true to and mimic real-life objects, such as the bookshelf in the iBooks icon, green felt in its Game Center app icon, and an analog clock depicting the time.


Forstall, who will stay on as adviser to Cook for another year, strongly believed in these designs, but his philosophy was not shared by all. His chief dissenter was Ive, who is said to prefer a more open approach, which could mean a slightly different design direction on the icons.


"There is no one else who has that kind of (design) focus on the team," the person said of Ive. "He is critical for them."


(Additional reporting by Alistair Barr; Editing by Edwin Chan and Ken Wills)

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The Devil’s General? German film seeks to debunk Rommel myth

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BERLIN (Reuters) – Erwin Rommel, the World War Two German field marshal celebrated as the brilliant and humane “Desert Fox“, is portrayed in a new film as a weak man torn by his loyalty to Adolf Hitler and the dawning realization that he was serving a devil.


The drama, due to be broadcast on the public ARD television on Thursday, has angered Rommel‘s son and granddaughter who believe it underplays his role in the resistance against Hitler.





















Rommel was forced to commit suicide in 1944 after Hitler suspected the general of being linked to the July 1944 plot to kill him, though historians disagree about how close he was to the failed assassination attempt.


Nazi propaganda feted Rommel as a military genius after his successful, bold offensives against the Allies in North Africa from 1941 until late 1942 when his Afrikakorps was defeated at El Alamein, a battle commemorated in London last week by the dwindling band of surviving British and Commonwealth veterans.


Even wartime British Prime Minister Winston Churchill hailed Rommel as a “great general”.


Rommel’s standing among his enemies was enhanced by his humane treatment of prisoners. The Afrikakorps eschewed the atrocities committed by the German army in other theatres of war, especially on the Eastern Front.


By 1944, in Normandy trying to defend the coast from an impending Allied landing, Rommel realized the war was lost and grew disillusioned. Despite having links to some of the plotters, he never joined the abortive July 20, 1944 conspiracy to assassinate Hitler.


“The idea is to demystify Rommel,” producer Nico Hofmann told Reuters.


“There is a lot of speculation surrounding the myth of Rommel. To some he is a brave, proud soldier, the ‘Desert Fox’. Some people don’t know he committed suicide under pressure from Hitler and think he perished in the war and there are many questions about how close he was to the resistance.”


“These are taboos, subjects for discussion and historical evaluation,” he said.


Film director Niki Stein described Rommel as a “weak man” who chose to look away and many historians say he was primarily bent on serving Hitler to advance his career.


Rommel’s family has denounced the script of the 6 million euro film which focuses on his growing internal conflict during the seven months of his life leading up to his death.


His son, Manfred – who was 15 when his father died and is now 83 – and granddaughter wrote to the producers last year accusing the script of the film “Rommel” of presenting “lies”.


They argued that he played a greater role in the resistance than the producers believed, said Hofmann.


The family have declined to talk to media about the film.


CYANIDE ULTIMATUM


Historians say the film is important as it will show millions of viewers the dramatic last months of the general’s life and the dilemma faced by many Germans who felt a sense of duty to their country, but were disenchanted with Hitler.


“Please watch, this film explains a little how it was back then with our grandparents, with Hitler, with fear, with joining in,” wrote a columnist in top-selling Bild daily, which has been serializing Rommel’s life.


“The Rommel film shows how a man believes he is serving a king and realizes too late that he is a devil.”


Other newspapers have also run long articles on the Rommel figure and the authoritative weekly Der Spiegel splashed “The Myth of Erwin Rommel” on its cover this week.


The film shows how a conflicted general, who was one of the Nazi regime’s biggest propaganda tools, gradually turned against Hitler. In line with the historical evidence, it leaves open his role in the plot against Hitler led by Claus von Stauffenberg.


Although he had contact with some of those involved, his son has written that he knew nothing of the assassination attempt.


Rommel was wounded by a Spitfire attack on his staff car days before the July 20 coup attempt, but soon after the plot ringleaders were executed Hitler grew suspicious about him.


Realizing the potential damage of putting Rommel on trial for treason, Hitler sent two officers to put an ultimatum to his once favorite general: if he wanted his wife and son to be looked after, he should swallow a cyanide capsule.


Hitler wrote to his widow and gave the field marshal a state funeral with his coffin draped in a swastika flag.


“I don’t see him as a hero. He is a tragic figure. He was a weak man drawn into an incredible internal conflict,” Stein, the director and author of the screenplay, told Reuters.


“I hope young Germans watch. We’re talking about our grandparents. It explains a lot about the way people act in a dictatorship.”


With popular actor Ulrich Tukur playing the main role, Stein thinks people will identify with Rommel but not necessarily sympathize with him. “Perhaps they will be shocked when they realize he is not so clean,” he said.


Underscoring the many contradictions of his character, Rommel’s legacy has shifted over the years.


Immediately after World War Two, Germans latched on to the myth of Rommel as a “soldier’s soldier” who had no close links to Nazi ideology and was forced to kill himself by the regime.


Much was made of the behavior of his Afrikakorps and his decision to disobey Hitler’s “victory or death” order at El Alamein and instead oversee a retreat which saved many lives.


“By the 1970s a German destroyer and army barracks were named after him,” said history Professor Soenke Neitzel, who has written about Rommel and advised the filmmakers.


He was favorably portrayed in 1951 by James Mason in “The Desert Fox”, which gave prominence to his disputed role in the von Stauffenberg plot.


But many historians say it is implausible that a field marshal who regularly met top Nazis, including Hitler, did not know of the Holocaust, a point critics say the film brushes over.


“On the one hand he didn’t commit war crimes that we know of and ordered a retreat at El Alamein despite Hitler’s order,” said Neitzel.


“But he took huge German casualties elsewhere and he was a servant of the regime. He was not exactly a shining liberal or Social Democrat. Mostly, he was interested in his career.”


(Editing by Jon Hemming)


Movies News Headlines – Yahoo! News



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High-protein diet may help some people shed pounds

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NEW YORK (Reuters Health) – Dieters who eat meals and snacks high in protein might lose a bit more weight than those who get less protein and more carbohydrates – all other things being equal, a new analysis of past studies suggests.


Researchers found that over an average of 12 weeks, people assigned at random to a high-protein diet lost about 1.8 extra pounds, and more body fat, than those assigned to a standard-protein diet.





















There was no difference, however, in how much participants’ blood pressure, cholesterol levels or markers for diabetes risk changed based on the protein content of their diets.


Thomas Wycherley from the University of South Australia in Adelaide, the lead author on the study, said in an email to Reuters Health that the extra weight loss in the high-protein group was “only modest,” but that “it may still represent clinical relevance on a population level.”


For the study, he and his colleagues analyzed 24 past trials that included a total of 1,063 people.


Participants were all put on a reduced-calorie, low-fat diet designed to help them lose weight. About half were prescribed a high-protein version of that diet – containing about 85 grams of protein per day for a 150-pound person – and the other half a standard-protein diet, with 49 grams per day, on average, for a 150-pound person.


Across all trials, high-protein and standard-protein diets were designed to provide the same calorie reduction.


Depending on the study, participants lost an average of anywhere from 2.4 to 25.1 pounds, according to findings published last week in The American Journal of Clinical Nutrition.


It’s not obvious why a higher protein-to-carbohydrate ratio might help people shed more pounds – and one obesity researcher not involved in the new analysis questioned whether the trials were even robust enough to make that conclusion.


“The studies are generally far too short to tell impact,” Dr. James Levine from the Mayo Clinic in Scottsdale, Arizona, told Reuters Health in an email. What’s more, he added, “many are inadequately conducted to be relevant.”


Wycherley said it’s possible the body may spend more energy, and burn more calories, processing protein compared to carbohydrates. Another potential explanation for the link his team observed is that eating protein helps preserve muscle mass – and muscle mass burns more calories, even when the body is resting, than other types of mass.


He said people in the studies tended to get protein from a variety of animal and vegetable sources. Vegetable sources of protein include beans and other legumes.


Substituting protein for carbohydrates as part of an energy-restricted diet, Wycherley said, is one option for people hoping to lose weight.


But given the limitations of the current evidence, Levine said, “it makes no real difference which of the (weight-loss) approaches one chooses.”


SOURCE: The American Journal of Clinical Nutrition, online October 24, 2012.


Health News Headlines – Yahoo! News



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Storm death toll up, gas lines grow

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NEW YORK (Reuters) - New Yorkers awoke to the rumble of subway trains for the first time in four days on Thursday and the death toll continued to rise from the former hurricane Sandy, one of the biggest and most devastating storms ever to hit the United States.


Lines formed at gas stations amid fuel shortages around the U.S. Northeast and emergency utility crews struggled to reach the worst hit areas and restore power to millions of people.


At least 82 people in North America died in the superstorm, which ravaged the northeastern United States on Monday night, and officials said the count could climb higher as rescuers searched house-to-house through coastal towns.


More deaths were recorded overnight as the extent of destruction became clearer in the New York City borough of Staten Island, where the storm lifted whole houses off their foundations.


Authorities recovered 15 bodies from Staten Island. Among those still missing were two boys aged 4 and 2 who were swept from their mother's arms by the floodwaters, the New York Post reported. In all, 34 people died in New York City.


In hard-hit New Jersey, where oceanside towns saw entire neighborhoods swallowed by seawater and the Atlantic City boardwalk was destroyed, the death toll doubled to 12.


New Jersey favorite son Bruce Springsteen, along with Jon Bon Jovi and Sting, will headline a benefit concert for storm victims Friday night on NBC television, the network announced.


Sandy started as a late-season hurricane in the Caribbean, where it killed 69 people, before smashing ashore in the United States with 80 mph winds. It stretched from the Carolinas to Connecticut and was the largest storm by area to hit the United States in decades.


About 4.7 million homes and businesses in 15 U.S. states were without power on Thursday, down from a high of nearly 8.5 million, which surpassed the record 8.4 million customers who went dark from last year's Hurricane Irene.


Sandy made landfall in New Jersey with a full moon around high tide, creating a record storm surge that flooded lower Manhattan. By Thursday, the storm had dissipated over the North American mainland.


After a three-day hiatus, President Barack Obama was due to return to the campaign trail on Thursday, boosted in his re-election bid by a resounding endorsement of his disaster response from the Republican governor of New Jersey.


The Democratic incumbent, tied in polls with Mitt Romney before Tuesday's election, begins a two-day trip to the swing states of Colorado, Ohio and Nevada while his Republican challenger travels to Virginia.


Obama viewed flooded and sand-swept New Jersey shore communities on a helicopter tour of the state with Republican Governor Chris Christie on Wednesday.


"The entire country's been watching. Everyone knows how hard Jersey has been hit," Obama told people at an evacuation shelter in the town of Brigantine.


In New York, limited train service returned on some train and subway lines, but more than half of the gas stations in the city and neighboring New Jersey remained shut due to power outages and depleted fuel supplies. Even before dawn, long lines formed at gas stations that were expected to open.


Fuel supplies into New York and New Jersey were being choked off in several ways. Two refineries that make up a quarter of the region's refining capacity were still idle due to power outages or flooding. The New York Harbor waterway that imports a fifth of the area's fuel was still closed to traffic, and major import terminals were damaged and powerless.


In addition, the main oil pipeline from the Gulf Coast, which pumps 15 percent of the East Coast's fuel, remained shut.


Matthew Gessler of Brooklyn went to Breezy Point, a New York neighborhood where fire destroyed 111 homes, to inspect damage to his mother's house. Like others, he likened it to a war zone.


He said you could take a picture of the devastation and say it was the Middle East "and no one would doubt you at all."


In Jersey City, across the Hudson River from New York, drivers negotiated intersections without the aid of traffic lights. Shops were shuttered and lines formed outside pharmacies while people piled sodden mattresses and furniture along the side of the roads. The city has issued a curfew on people as well as a driving ban from 7 p.m. to 7 a.m.


New Yorkers faced an easier commute as the subway system resumed limited operations. But four of the seven subway tunnels under the East River remained flooded and there was no service in Manhattan below 34th Street, where the power is still out.


Subway rides were free as authorities encouraged commuters to use mass transit rather than drive. Mayor Michael Bloomberg and state Governor Andrew Cuomo said private cars must carry at least three people in order to enter New York, after the city was clogged by traffic on Wednesday.


LaGuardia airport in New York was scheduled to reopen on Thursday with limited service. John F. Kennedy and Newark, New Jersey, airports reopened with limited service on Wednesday.


(Additional reporting by Michael Erman, Anna Louie Sussman, Atossa Abrahamian, Martinne Geller and Scott DiSavino in New York, Susan Heavey in Washington, Ian Simpson in West Virginia and Mark Felsenthal in Atlantic City, N.J.; Writing by Eddie Evans and Daniel Trotta)


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Syrian air force on offensive after failed truce

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AMMAN (Reuters) – Syrian warplanes bombed rebel targets with renewed intensity on Tuesday after the end of a widely ignored four-day truce between President Bashar al-Assad‘s forces and insurgents.


State television said “terrorists” had assassinated an air force general, Abdullah Mahmoud al-Khalidi, in a Damascus suburb, the latest of several rebel attacks on senior officials.





















In July, a bomb killed four of Assad‘s aides, including his brother-in-law Assef Shawkat and the defense minister.


Air strikes hit eastern suburbs of Damascus, outlying areas in the central city of Homs, and the northern rebel-held town of Maarat al-Numan on the Damascus-Aleppo highway, activists said.


Rebels have been attacking army bases in al-Hamdaniya and Wadi al-Deif, on the outskirts of Maarat al-Numan.


Some activists said 28 civilians had been killed in Maarat al-Numan and released video footage of men retrieving a toddler’s body from a flattened building. The men cursed Assad as they dragged the dead girl, wearing a colorful overall, from the debris. The footage could not be independently verified.


The military has shelled and bombed Maarat al-Numan, 300 km (190 miles) north of Damascus, since rebels took it last month.


“The rebels have evacuated their positions inside Maarat al-Numaan since the air raids began. They are mostly on the frontline south of the town,” activist Mohammed Kanaan said.


Maarat al-Numan and other Sunni towns in northwestern Idlib province are mostly hostile to Assad’s ruling system, dominated by his minority Alawite sect, an offshoot of Shi’ite Islam.


Two rebels were killed and 10 wounded in an air strike on al-Mubarkiyeh, 6 km (4 miles) south of Homs, where rebels have besieged a compound guarding a tank maintenance facility.


Opposition sources said the facility had been used to shell Sunni villages near the Lebanese border.


“WE’LL FIX IT”


The army also fired mortar bombs into the Damascus district of Hammouria, killing at least eight people, activists said.


One video showed a young girl in Hammouria with a large shrapnel wound in her forehead sitting dazed while a doctor said: “Don’t worry dear, we’ll fix it for you.”


Syria’s military, stretched thin by the struggle to keep control, has increasingly used air power against opposition areas, including those in the main cities of Damascus and Aleppo. Insurgents lack effective anti-aircraft weapons.


U.N.-Arab League envoy Lakhdar Brahimi has said he will pursue his peace efforts despite the failure of his appeal for a pause in fighting for the Muslim Eid al-Adha holiday.


But it is unclear how he can find any compromise acceptable to Assad, who seems determined to keep power whatever the cost, and mostly Sunni Muslim rebels equally intent on toppling him.


Big powers and Middle Eastern countries are divided over how to end the 19-month-old conflict which has cost an estimated 32,000 dead, making it one of the bloodiest of Arab revolts that have ousted entrenched leaders in Tunisia, Egypt and Libya.


The United Nations said it had sent a convoy of 18 trucks with food and other aid to Homs during the “ceasefire”, but had been unable to unload supplies in the Old City due to fighting.


“We were trying to take advantage of positive signs we saw at the end of last week. The truce lasted more or less four hours so there was not much opportunity for us after all,” said Jens Laerke, a U.N. spokesman in Geneva.


The prime minister of the Gulf state of Qatar told al-Jazeera television late on Monday that Syria’s conflict was not a civil war but “a war of annihilation licensed firstly by the Syrian government and secondly by the international community”.


Sheikh Hamad bin Jassim al-Thani said some of those responsible were on the U.N. Security Council, alluding to Russia and China which have vetoed three Western-backed U.N. draft resolutions condemning Assad.


He said that the West was also not doing enough to stop the violence and that the United States would be in “paralysis” for two or three weeks during its presidential election.


(Additional reporting by Raissa Kasolowsky in Abu Dhabi and Stephanie Nebehay in Geneva; Writing by Oliver Holmes; Editing by Alistair Lyon)


World News Headlines – Yahoo! News



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In hurricane, Twitter proves a lifeline despite pranksters

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SAN FRANCISCO (Reuters) - As Hurricane Sandy pounded the U.S. Atlantic coast on Monday night, knocking out electricity and Internet connections, millions of residents turned to Twitter as a part-newswire, part-911 hotline that hummed through the night even as some websites failed and swathes of Manhattan fell dark.


But the social network also became a fertile ground for pranksters who seized the moment to disseminate rumors and Photoshopped images, including a false tweet Monday night that the trading floor at the New York Stock Exchange was submerged under several feet of water.


The exchange issued a denial, but not before the tweet was circulated by countless users and reported on-air by CNN, illustrating how Twitter had become the essential - but deeply fallible - spine of information coursing through real-time, major media events.


But a year after Twitter gained attention for its role in the rescue efforts in tsunami-stricken Japan, the network seemed to solidify its mainstream foothold as government agencies, news outlets and residents in need turned to it at the most critical hour.


Beginning late Sunday, government agencies and officials, from New York Governor Andrew Cuomo(@NYGovCuomo) to the Federal Emergency Management Agency (@FEMA) to @NotifyNYC, an account handled by New York City's emergency management officials, issued evacuation orders and updates.


As the storm battered New York Monday night, residents encountering clogged 9-1-1 dispatch lines flooded the Fire Department's @fdny Twitter account with appeals for information and help for trapped relatives and friends.


One elderly resident needed rescue in a building in Manhattan Beach. Another user sent @fdny an Instagram photo of four insulin shots that she needed refrigerated immediately. Yet another sought a portable generator for a friend on a ventilator living downtown.


Emily Rahimi, who manages the @fdny account by herself, according to a department spokesman, coolly fielded dozens of requests, while answering questions about whether to call 311, New York's non-emergency help line, or Consolidated Edison.


At the Red Cross of America's Washington D.C. headquarters, in a small room called the Digital Operations Center, six wall-mounted monitors display a stream of updates from Twitter and Facebook and a visual "heat map" of where posts seeking help are coming from.


The heat map informed how the Red Cross's aid workers deployed their resources, said Wendy Harman, the Red Cross director of social strategy.


The Red Cross was also using Radian6, a social media monitoring tool sold by Salesforce.com, to spot people seeking help and answer their questions.


"We found out we can carry out the mission of the Red Cross from the social Web," said Harman, who hosted a brief visit from President Barack Obama on Tuesday.


SPREADING INFORMATION


Twitter, which in the past year has heavily ramped up its advertising offerings and features to suit large brand marketers like Pepsico Inc and Procter & Gamble, suddenly found itself offering its tools to new kind of client on Monday: public agencies that wanted help spreading information.


For the first time, the company created a "#Sandy" event page - a format once reserved for large ad-friendly media events like the Olympics or Nascar races - that served as a hub where visitors could see aggregated information. The page displayed manually- and algorithmically-selected tweets plucked from official accounts like those of New York Mayor Michael Bloomberg and Governor Chris Christie of New Jersey, who was particularly active on the network.


Agencies like the Maryland Emergency Management Agency and the New York Mayor's Office also used Twitter's promoted tweets - an ad product used by advertisers to reach a broader consumer base - to get out the word.


The company said offering such services for free to government agencies was one of several initiatives, including a service that broadcasts location-specific alerts and public announcements based on a Twitter user's postal code.


"We learned from the storm and tsunami in Japan that Twitter can often be a lifeline," said Rachael Horwitz, a Twitter spokeswoman.


Jeannette Sutton, a sociologist at the University of Colorado who has received funding from the National Science Foundation and the Department of Homeland Security to study social media uses in disaster management, said government agencies have been skeptical until recently about using social media during natural disasters.


"There's a big problem with whether it's valid, accurate information out there," Sutton said. "But if you're not part of the conversation, you're going to be missing out."


As the hurricane hit one of the most wired regions in the country, news outlets also took advantage of the smartphone users who chronicled rising tides on every flooded block. On Instagram, the photo-sharing website, witnesses shared color-filtered snapshots of floating cars, submerged gas stations and a building shorn of its facade at a rate of more than 10 pictures per second, Instagram founder Kevin Systrom told Poynter.org on Tuesday.


Many of the images were republished in the live coverage by news websites and aired on television broadcasts.


LIES SLAPPED DOWN


But by late Monday, fake images began to circulate widely, including a picture of a storm cloud gathering dramatically over the Statue of Liberty and a photoshopped job of a shark lurking in a submerged residential neighborhood. The latter image even surfaced on social networks in China.


Then there was the slew of fabricated message from @comfortablysmug, the Twitter account that claimed the NYSE was underwater. The account is owned by Shashank Tripathi, the hedge fund investor and campaign manager for Christopher Wight, the Republican candidate to represent New York's 12th District in the U.S. House of Representatives.


Tripathi, who did not return emails by Reuters seeking comment, apologized Tuesday night for making a "series of irresponsible and inaccurate tweets" and resigned from Wight's campaign.


His identity was first reported by Jack Stuef of BuzzFeed.


Around 3:30 p.m. on Tuesday, Tripathi began deleting many of his Hurricane Sandy tweets. Tripathi's friend, @theAshok, defended Tripathi, telling Reuters on Twitter: "People shouldn't be taking "news" from an anonymous twitter account seriously."


Tripathi's @comfortablysmug's Twitter stream, which is followed by business journalists, bloggers and various New York personalities, had been a well-known voice in digital circles, but mostly for his 140-character-or-less criticisms of the Obama administration, often accompanied by the hashtag, #ObamaIsn'tWorking.


On Tuesday, New York City Councilman Peter F. Vallone Jr. appeared to threaten Tripathi with prosecution when he tweeted that he hoped Tripathi was "less smug and comfortable cuz I'm talking to Cy," presumably referring to Manhattan District Attorney Cyrus Vance Jr.


For its part, Twitter said that it would not have considered suspending the account unless it received a request from a law enforcement agency.


"We don't moderate content, and we certainly don't want to be in a position of deciding what speech is OK and what speech is not," said Horwitz, Twitter's spokeswoman.


But Ben Smith, the editor at Buzzfeed, which outed Tripathi, said Twitter's credibility would not be affected by rumormongers because netizens often self-correct and identify falsehoods.


"They used to say a lie will travel halfway around the world before the truth puts its shoes on, but in the Twitter world, that's not true anymore," Smith said. "The lies get slapped down really fast."


For Smith, the ability to disseminate information via Twitter and Facebook on Monday night became perhaps even more important than his Web publication, which enjoyed one of its better nights in readership but went dark when the blackout crippled the site's servers in downtown Manhattan.


Buzzfeed's staff quickly began publishing on Tumblr instead, and Smith personally took over Buzzfeed's Twitter account to stay in the thick of the conversation.


"Our view of the world is that social distribution is the key thing," Smith said. "We're in the business of creating content that people want to share, more than the business of maintaining a website."


(Reporting By Gerry Shih in San Francisco and Jennifer Ablan and Felix Salmon in New York; Editing by Robert Birsel)


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“Community” returning to old time slot in February

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NEW YORK (TheWrap.com) – “Community” will return Thursday, February 7 to its previous timeslot after a long absence from NBC‘s lineup.


NBC confirmed the show’s return date soon after star Yvette Nicole Brown, who plays Shirley on the ensemble comedy, announced the news on Twitter.





















“Guys, #Community officially has an airdate: Thursday, February 7th at 8pm!,” tweeted the actress. NBC also announced several others return and premiere dates Tuesday.


The move means the network has abandoned its plans to move the show to Friday nights. “Community” will take the place of “30 Rock,” which will have completed its 13-episode final season by February.


“Community” was scheduled to move to Fridays beginning on October 19. But NBC opted to delay the Friday debut of “Community” and “Whitney” so it could devote itself to promoting its new fall comedies.


When one of them, “Animal Practice,” was cancelled, its timeslot went to “Whitney,” and the fate of “Community” was left up in the air.


Despite the long delay – “Community” hasn’t aired since the spring – the Thursday timeslot is good news for the show since Fridays usually draw much lower ratings.


NBC fired “Community” creator and showrunner Dan Harmon at the end of last season. Though it is critically acclaimed and has many diehard fans online, that hasn’t translated into many viewers.


NBC’s entertainment chairman has said that the network wants to focus more this season on broad comedies than on its quick-witted but odd Thursday shows, which tend to struggle for ratings.


TV News Headlines – Yahoo! News



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European austerity hits GlaxoSmithKline Q3 profit

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LONDON (AP) — Drug company GlaxoSmithKline saw its third-quarter fall by nearly a fifth as sales fell in Europe and the United States.


GSK reported Wednesday that its net profit declined 18 percent to 1.12 billion pounds ($ 1.8 billion) in the three months ending Sept. 30, from 1.38 billion pounds in the same period last year.





















Revenue fell 8 percent to 6.5 billion pounds with sales 9 percent lower in Europe, where the company faced pricing pressure from government austerity drives. U.S. sales fell 6 percent because of generic competition, the end of a co-promotion agreement for incontinence drug Vesicare and declining sales of Avandia for diabetes.


Avandia was banned in Europe in 2010 and sales were severely restricted in the United States after it was found to sharply increase the risk of heart attacks and congestive heart failure. In July, GSK agreed to pay $ 3 billion to settle a criminal and civil liability claims by the U.S. government and several states.


Sales in emerging markets rose 11 percent — led by a 16 percent advance in the Middle East and Africa —and overtook Europe as the company’s biggest market in terms of revenue.


The company raised its quarterly dividend by 6 percent to 18 pence.


However, GSK shares were down 0.7 percent at 1,410 pence at midday.


“The group’s results have again failed to inspire,” said Keith Bowman, analyst at Hargreaves Lansdown Stockbrokers. “Europe continues to weigh, whilst hoped-for new product sales are yet to compensate for disposals and tough comparatives.”


Chief Executive Andrew Witty was optimistic of prospects for new drugs in development. The company expects to begin regulatory filings around the end of the year for respiratory medicine LAMA/LABA, HIV drug dolutegravir and diabetes medicine albiglutide.


“With sales contributions from new products, together with further cost discipline, we remain confident that we can drive improvements in core operating margin over the next few years,” Witty said.


He added that “absent a further deterioration in Europe, we now expect sales for the year to be broadly in line with 2011 on a constant currency basis.”


During the quarter, GSK completed the acquisition of Human Genome Sciences, based in Rockville, Maryland, for 2.5 billion pounds, and expects to spend 233 million pounds on restructuring.


The company has spent 1.9 billion pounds on share repurchases this year, and expects the full year total to be as much as 2.5 billion pounds.


Medications/Drugs News Headlines – Yahoo! News



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